A recent study published in the Journal of the American Academy of Dermatology has shown that taking hydrochlorothiazide (HCTZ) is associated with an increased risk of basal cell carcinoma and an even higher risk of squamous cell carcinoma. The risk was dose dependent (the higher the cumulative dose, the higher the risk).
An increased risk was not seen with other anti-hypertensive agents or diuretics.
A recent study has shown a positive association of increased alcohol consumption with the risk of non-melanoma skin cancer. The study was small, so larger studies are needed to confirm these preliminary results.
Here is yet another possible reason to limit or eliminate alcohol consumption. Red wine has some other health benefits that, according to some, might outweigh the negative effects when taken in moderation–no more than one glass per day, but even that is somewhat controversial.
The use of PDE5 inhibitors such as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra) are common for those with erectile dysfunction. More and more research has shown an increased risk of some types of skin cancer for those taking these medications. Interestingly, there have been no studies showing an increased risk of squamous cell carcinoma.
For this reason, those with a history of melanoma should take this into consideration when considering taking one of these medications. Those with a personal history of multiple dysplastic moles or family history of melanoma should also take this into consideration. For patients whom have had multiple basal cell carcinomas should also weigh the risks of taking these medications.